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Select fetal trophoblast invade into the maternal decidua and remodel and line maternal arteries, facilitating maternal blood to flow into the fetal portion of the placenta ( Adamson et al., 2002 Maltepe and Fisher, 2015). The mouse placenta is separated into three main regions – the decidua, the junctional zone (JZ), and the labyrinth. The placenta performs many essential functions including transport of nutrients and exchange of gases and waste between maternal and fetal blood, production and uptake of hormones, and regulation of the maternal immune system ( Maltepe and Fisher, 2015 Woods et al., 2018). The placenta links maternal tissues and the embryo, providing necessary support and instructing the development of the embryo. These data profile placental development at an unprecedented resolution, provide insights into differentiation and function across time, and provide a resource for future study.
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#GEMCRAFT LABYRINTH W DRIVERS#
Analysis by snRNA-seq identified transcript profiles and inferred functions, cell trajectories, signaling interactions, and transcriptional drivers of all but the most highly polyploid cell types of the placenta.
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Timepoints extended from progenitor-driven expansion through terminal differentiation. Here, we address questions concerning the ontogeny, specification, and function of the cell types of a representative hemochorial placenta by performing single nuclei RNA sequencing (snRNA-seq) at multiple stages of mouse embryonic development focusing on the exchange interface, the labyrinth. A substantial challenge has been the syncytial cells of the placenta, which have made dissociation and independent evaluation of the different cell types of this organ difficult. However, our understanding of this essential organ remains incomplete. The placenta is the interface between mother and fetus in all eutherian species.